Explore cruises departing from San Francisco, the perfect place to kick off your dream cruise vacation. With its stunning scenery and one-of-a-kind culture, San Francisco is a destination hotspot in a class of its own. Take in the magnificent architecture of the Golden Gate Bridge, sample some fine chocolate and sweets in Ghirardelli Square, or take a tour of Alcatraz, the world’s most famous island prison. Arrange a pre- or post-cruise stay in San Francisco to take in this city’s magnificent culture.

From San Francisco, you can cruise to Alaska, Hawaii, or undertake a Transpacific itinerary to Australia or the South Pacific. Or cruise the Mexican Riviera, stopping at landmark destinations such as Ensenada, Mazatlan, or Cabo San Lucas. Search from dozens of cruises from San Francisco on Dreamlines today. With popular itineraries from top cruise lines such as Princess Cruises, Carnival Cruise Line, and Oceania Cruises, Dreamlines is the perfect place to book your cruise from San Francisco.